Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.

TitleInvariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Publication TypeJournal Article
Year of Publication2014
AuthorsLee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P
JournalProc Natl Acad Sci U S A
Volume111
Issue38
Start Page13936
Date Published09/2014
Keywordsgranzyme B, joint iNKT cells, Lyme arthritis
Abstract

Successful penetrance of B. burgdorferi out of the vasculature and into the joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pathway, an observation also made in vitro for iNKT cells from joint but not liver or spleen. These results suggest a novel, critical extravascular iNKT cell immune surveillance in joints that functions as a cytotoxic barrier and explains a large increase in pathogen burden of B. burgdorferi in the joint of iNKT cell-deficient mice, and perhaps the greater susceptibility of humans to this pathogen because of fewer iNKT cells in human joints.

URLhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183287/
DOI10.1073/pnas.1404769111