Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity

TitleInfection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity
Publication TypeJournal Article
Year of Publication2016
AuthorsZlotnikov, N, Javid, A, Ahmed, M, Eshghi, A, Tang, TTian, Arya, A, Bansal, A, Matar, F, Parikh, M, Ebady, R, Koh, A, Gupta, N
JournalCellular microbiology
Date Published11/2016
Keywordsdisease, immune, lyme, obesity, suppression
Abstract

Obesity is a major global public health concern. Immune responses implicated in obesity also control certain infections. We investigated the effects of high-fat diet-induced obesity (DIO) on infection with the Lyme disease bacterium Borrelia burgdorferi in mice. Importantly, innate immune suppression increased with infection duration and depended on cooperative and synergistic interactions between DIO and B. burgdorferi infection. Thus, obesity and B. burgdorferi infection cooperatively and progressively suppressed innate immunity in mice.

URLhttp://onlinelibrary.wiley.com/doi/10.1111/cmi.12689/full
DOI10.1111/cmi.12689