Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen

TitleHyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen
Publication TypeJournal Article
Year of Publication2016
AuthorsJavid, A, Zlotnikov, N, Pětrošová, H, Tang, TTian, Zhang, Y, Bansal, AK, Ebady, R, Parikh, M, Glogauer, M, Moriarty, TJ, Ahmed, M, Kim, YRam, Sosa, MSantana, Sun, C, Newbiggin, S
JournalPLoS One
Volume11
Issue6
Start Page e0158019
Date Published06/2016
Keywordsbacteria, borrelia, burgdorferi, diabetes, lyme, mice, neutrophils
Abstract

The present study investigated the impact of sustained obesity-independent hyperglycemia in mice on bacterial clearance, inflammatory pathology and neutrophil responses to B. burgdorferi. These data suggest that investigating the effects of comorbid conditions such as diabetes on outcomes of B. burgdorferi infections in humans may be warranted.

URLhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920391/